I am personally not looking forward to this Villains Month crap. Some titles will be getting weekly books, other titles will simply not be published that month, or they might get 1, 2, 3 or 4 books.
And it's gonna be a PITA for the database.
Even though some titles will get weekly books, it's still just 52 books - there are some titles (like StormWatch, whose current villain, Lobo, will be in Justice League 23.2, or Worlds' Finest since Earth 2 is getting 2 issues that month). In fact, many titles won't have books out in September: All-Star Western, Animal Man, Batgirl, Batman and..., Batwing, Batwoman, Birds of Prey, Catwoman, Constantine, Demon Knights, Dial H, Green Lantern Corps, Green Lantern: New Guardians, The Green Team, Katana, Larfleeze, Legion of Super-Heroes, The Movement, Nightwing, Red Hood, Red Lanterns, StormWatch, Suicide Squad, Superboy, Supergirl, Superman Unchained, Talon, Threshold, Trinity of Sin: Pandora, Trinity of Sin: Phantom Stranger, Vibe, and Worlds' Finest will all skip issues in September.
As for adding them to the DB, there will be no problems with this. We know how to add #.# issues. They'll just be a little difficult for some people to find, but adding a "Villains Month" tag will help with that.
What I don't like about Villain's month is that all issues jump up to $3.99. On the plus side, it's an excellent time for me to drop titles.