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monidaw1
Sunday, June 28, 2020 12:44:22 PM
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Quote:
Eli Lilly and Co could have a drug specifically designed to treat COVID-19 authorized for use as early as September if all goes well with either of two antibody therapies it is testing, its chief scientist told Reuters on Wednesday.


Quote:
Lilly has already launched human trials with two of the experimental therapies.


https://www.livemint.com/science/health/lilly-s-covid-19-drug-could-be-ready-for-use-as-soon-as-sept-says-chief-scientist-11592911375847.html


Anyone else getting excited to see a large number of treatments, curatives and vaccines already in human trials or expected to be before the end of July?

Every day it seems I see another one getting very little news media attention moving into human testing.

It appears most of them are starting mass production ahead of approval so a large number of doses will be available to treat the sickest individuals very soon if any of the array get approved. The biggest gun of all isn't far away either if it lives up to the already announced expectations. Human testing by the end of July for that one also.

It appears first one to market gets the prize. The best one gets duplicated all over the world by other labs and countries. It appears in the case of the antibody treatments, they aren't inventing anything, just identifying it and mass producing them so the 1st one to market will only have a limited window of financial lucrativity before the knockoffs and duplicates kill the market.

It almost feels like I'm at the Kentucky Derby and the horses are entering the final stretch run.

If you haven't been keeping track at home there's in the Keep I Simple Stupid (KISS) method of describing them
1- Drugs for treatment of the symptoms
2- Vaccine that hopes to give you immunity by causing you to develop antibodies.
3- Plasma Therapy where people who are recovered donate plasma with antibodies to help others recover.
4- Antibody treatments

Plasma Therapy becomes more available every single day as more and more people get the virus and recover. For example, Virginia has over 60,000 confirmed cases. The CDC says we're most likely off by a factor of 10 so that means we realistically may have as many as 600,000 people already capable of donating plasma to help others recover. Plasma though is a more labor intensive and expensive option while introducing unneeded random extras into the mix that may help or even hinder the overall results in some.

Antibody treatments are basically taking the one or more specific antibodies and duplicating them. The drawback here is if they aren't very affective it can only really be done with a full plasma level transfusion type treatment. That escalates the costs and reduces the production rates. That also limits where it can be used.

If the antibody is very affective it can be used in smaller doses given by injection the way I understand it. The advantages here mean a much larger amount can be produced and the easier to administer and distribute injections can reach a larger portion of the population. Some are using multiple antibodies together. While good, if they have to produce say 3 different antibodies to mix together, then that cuts production almost to 1/3rd. The goal here is to find the one that does it rapidly, 100% and can be mass produced cheaply and rapidly.

The antibodies then could also be used in place of a vaccine since they're directly doing what the vaccine is hoping to have the body accomplish.

Here's some more light reading on happier thoughts as the medical community in general appears to be getting better at treating all the time.



monidaw1
Thursday, July 02, 2020 12:03:18 PM
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Phizer's 1st human trails were successful and the next batch of 30,000 human's is about to begin. (Hoping for a thousand or so football players added in) They said they expect they could have 100 million doses by the end of the year which means an ever increasing supply daily ready to go once it's green lighted. Over a billion next year they said!!!!!

The leading experts if we were describing our attempts to fight a forest fire instead of a pandemic would come across as "I don't think Crewe Volunteer Fire department is going to be able to handle this and in reality that's most likely a true statement that supports whatever agenda they're pushing. The reality though is it isn't one small town's fire department fighting the fire and it isn't one company chasing a solution to the pandemic. You'd have fire departments from multiple towns attacking it from different angles, National Guard planes dumping loads of water from the air, contrustion companys donating bulldozers and personnel to clear fire breaks, and even forest rangers starting back burns to take away the fuel. No one alone will get it under control fast but the smaller successes of a lot of different groups operating together just about can't fail.

There are over 100 different vaccines, drugs, antibody treatments and cures already in rush development. Any number of them having success combined with the ever increasing amount of people who are already recovered should have this behind us rapidly.

OPEN the schools back up!!! They should have never been closed in the first place it seems.

Quote:
The death of even one child is tragic, of course. Yet, it must be kept in mind that as many as 600 children in the United States died from seasonal influenza in 2017-18, according to CDC estimates, while the CDC’s estimate for COVID-19 fatalities number just 12.
4saken1
Saturday, July 04, 2020 3:36:19 PM
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I am also excited about the prospect of various treatments and vaccines being developed by pharmaceutical companies. It will be interesting to see how badly they rape the American taxpayer for a treatment that will likely cost less than $5 to manufacture (thousands of dollars/dose, probably). Yes, there are upfront costs to doing research, but there should be a limit, particularly since most of these companies already get a s$!t ton of subsidies from the government.

monidaw1 wrote:
OPEN the schools back up!!! They should have never been closed in the first place it seems.

Quote:
The death of even one child is tragic, of course. Yet, it must be kept in mind that as many as 600 children in the United States died from seasonal influenza in 2017-18, according to CDC estimates, while the CDC’s estimate for COVID-19 fatalities number just 12.


The closing of schools has less to do with the children themselves becoming sick from the virus than them being carriers and getting family members sick. So yes, closing the schools was a good idea!

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monidaw1
Wednesday, July 22, 2020 10:32:19 AM
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https://www.msn.com/en-us/money/companies/u-s-orders-up-to-600-million-doses-of-pfizer-biontech-covid-vaccine/ar-BB17359Y?ocid=msedgntp

The US just ordered 100 million doses at a cost of $19.50 a dose of the vaccine the company said may be ready for emergency use approval as early as the beginning of September.

Quote:
The closing of schools has less to do with the children themselves becoming sick from the virus than them being carriers and getting family members sick. So yes, closing the schools was a good idea!


https://www.npr.org/2020/06/24/882316641/what-parents-can-learn-from-child-care-centers-that-stayed-open-during-lockdowns?fbclid=IwAR3KqklOYJVkYSp8CU_aUStN1OyE37H99SHp7QSWpc2XkQzsoYyTKv-HGyo

Plenty of articles out there showing data that children aren't causing outbreaks and transmitting the virus back to get households infected from multiple sources like the one above.

Plenty of examples of things that make no sense like why we can't have people donating plasma that have recovered, turned into up to 5000 shots to give immunity to teachers, frontline workers, etc. There's no real reason for anyone to be living in fear. Just today I'm reading studies from Sweden showing immunity can last for 6 months or longer even with antibody concentrations dropping from other factors the article explains well.

Even Sorrento is finally being allowed to get a horse or two in the race although the "cure" is still being dragged out of rapid development.

I just found this vaccine tracker from the New York Times that appears to be an ongoing that will update regularly.

Every day it seems another announcement of good news or fake data like the test kit giving 57% positive results for the last month they just identified.


Just found another article that appears to show the arm injections to inexpensively provide temporary immunity may have a shot at getting funded and approved finally after months and months of needless delays.
4saken1
Wednesday, July 29, 2020 11:45:28 AM
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Saw this one a few days ago:

UPDATED: More than 7,000 Children in Florida Have Tested Positive for COVID-19

Quote:
The CDC’s new guidelines exclude age as a factor for COVID-19 contagion as more than 7,000 kids test positive in Florida alone, according to the Department of Health. But that number continues to grow rapidly.


Then there's the issue of teachers themselves infecting each other. Nearly a third of all teachers are over 50 and at much higher risk,
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monidaw1
Wednesday, July 29, 2020 6:24:03 PM
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It now appears Russia has leap frogged the vaccine race with an August 10th potential for approval.

Two Democratic Congress people are now aware of and pushing for the little shots that could have been made available inexpensively months ago based on proven methods that would take a single donation of plasma and give up to 5,000 teachers and front line workers immunity for at least 2 months and possibly more if you folow the swedish reports of it lasting 6 months or longer even with antibodies reducing over time due to various other aspects.
https://www.msn.com/en-us/news/us/democratic-lawmakers-urge-funding-for-potential-covid-19-treatment/ar-BB171yqs?ocid=msedgntp

https://www.msn.com/en-us/money/other/sweden-says-covid-immunity-can-last-6-months-after-infection/ar-BB170ygs?ocid=msedgntp

The vaccine can be approved faster if they allow volunteers to get exposed. https://www.msn.com/en-us/health/medical/infecting-willing-volunteers-with-covid-19-might-speed-up-the-race-for-a-vaccine-but-it-could-be-risky-opinion/ar-BB17fOYQ?ocid=msedgntp

Even if teachers got infected it appears most asymptomatic wouldn't actually transit it to others according to WHO. If they were symptomatic then they would know to stay home. https://www.cnn.com/2020/06/08/health/coronavirus-asymptomatic-spread-who-bn/index.html

Even the "cure" and some of Sorrento's other products are finally squeaking thru as it's now been held back long enough to allow the vaccines to get to the finish line first. https://www.msn.com/en-us/money/topstocks/speculative-investors-should-buy-sorrento-stock/ar-BB17h2lq?ocid=msedgntp

There's also talk of having the world unite in the testing/approval so each vaccine doesn't have to go thru testing, over and over and over and over again and could be allowed in more countries faster based on solid data from one.

There's so much good news out there they can't possibly hold it all back much longer!!!!!! Dancing

Here's some more light reading and another article putting October for Phizer's vaccine as possible. https://www.msn.com/en-us/health/medical/solving-covid-july-22-2020/ar-BB173BId?ocid=msedgntp

I've lost count of how many are now in Phase 3 between the US, Brazil, Russia and Singapore.

Even total screwups like right down the road appear to be headed toward a happy ending. ICE facility thru idiocy managed to get about 90% of the facility and staff positive by not isolating new arrivals. https://www.wric.com/news/taking-action/covid-19-cases-spike-at-farmville-ice-detention-center-after-transfers-from-florida-arizona/?fbclid=IwAR15nuqBl8y440HR8DOs9RODsdulwYCWZInBehoUwfGVs7vKu9U-mc3wAMY The bright side there is at the time of that article only 3 people out of over 300 needed hospitalization and no deaths and hopefully the happy ending will come in a week or so when the last of them are recovered and immune at least until next year or longer.

And one more time, another article on the "cure" being slowed but still puttering along maybe taking as long as until October before they can't find ways to stop it from getting out. https://www.bioworld.com/articles/435404-optimistic-sorrento-looking-to-have-covid-19-antibody-ready-by-october


Quote:
Saw this one a few days ago:

UPDATED: More than 7,000 Children in Florida Have Tested Positive for COVID-19


And just this morning this gem saying more kids are dying from suicides and overdoses due to depression and other factors from not being in school.

Of course that is the head of the CDC so we already know we can't trust their opinion and of course they didn't provide the actual statistics which may not be available for two years.

Quote:
Then there's the issue of teachers themselves infecting each other. Nearly a third of all teachers are over 50 and at much higher risk,


That point brings up a few good points including why so few young people are entering the field that the number of older teachers is skewed so heavy. More pay, better working conditions, etc.. but that's another thread for another day. Overall though there are a number of things that should have that be less of a concern.

First of all there's absolutely no doubt that we could have already made available those shots that would give temporary immunity based on methods that have been in practice for a century or so now. Congress is even aware of it now, see the earlier links in this reply for more on that.

Second, I don't have a problem with having the older teachers staying home and/or working the internet classes and other options out there moving the younger teachers and those who have already had the virus and recovered to the classroom and frontline places. That should be common sense at this point to do just that.

Third, any of them that are at higher risk in any age group should have the option of extended unemployement benefits to stay home until a vaccine is ready and then they should be required to be near the top of the vaccine dispersements or risk losing that unemployement $$ when it's available.

Forth, these are overall, highly intelligent people who should have enough sense to learn the basics of sanitizing their classrooms for the kids and for themselves as well as doing what's required to keep themselves safe. if daycare workers can figure out basic safety hygiene practices then good ol Mrs Crabtree had better be able to do the same and be cable of teaching it and leading by example.

Fifth, once again, getting the virus isn't a death sentence. The news articles the last few days are starting to come out and show the fatality rates comparable to the same data released by Italy back in March.

Every week it seems more and more options for treatment are becoming available and doctors are getting better at treating in ways to keep people out of danger. A lot of mistakes were made early on but hopefully they continue to learn from those.



4saken1
Thursday, July 30, 2020 10:47:57 AM
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monidaw1 wrote:
First of all there's absolutely no doubt that we could have already made available those shots that would give temporary immunity based on methods that have been in practice for a century or so now. Congress is even aware of it now, see the earlier links in this reply for more on that.

Second, I don't have a problem with having the older teachers staying home and/or working the internet classes and other options out there moving the younger teachers and those who have already had the virus and recovered to the classroom and frontline places. That should be common sense at this point to do just that.

Third, any of them that are at higher risk in any age group should have the option of extended unemployement benefits to stay home until a vaccine is ready and then they should be required to be near the top of the vaccine dispersements or risk losing that unemployement $$ when it's available.


Yes, these are very nice coulds and shoulds, but I'm not entirely convinced that these would actually be enacted on a large scale, leaving many at substantial risk.

monidaw1 wrote:
Forth, these are overall, highly intelligent people who should have enough sense to learn the basics of sanitizing their classrooms for the kids and for themselves as well as doing what's required to keep themselves safe. if daycare workers can figure out basic safety hygiene practices then good ol Mrs Crabtree had better be able to do the same and be cable of teaching it and leading by example.


So if somebody becomes infected, it's just because they're stupid. Got it!

monidaw1 wrote:
Fifth, once again, getting the virus isn't a death sentence. The news articles the last few days are starting to come out and show the fatality rates comparable to the same data released by Italy back in March.


Yes, the mortality rate has been dropping as hospitals become more knowledgeable and equipped to deal with this pandemic. Another factor is that active cases had been dropping and there have been more ICU beds available for patients who needed care. As the significant uptick in cases we have experienced since earlier this month have begun to reach their later stages, however, this number has started to climb again. By late June, we were seeing deaths nationally average about 500 per day. Yesterday, there was 1,449! As hospitals become more and more crowded and are unable to handle all of the patients, this number will once again begin to explode.

Furthermore, death isn't the only thing that people who contract the virus need to worry about!

What we know (so far) about the long-term health effects of Covid-19

Quote:
Currently, it's estimated as few as 5% and as many as 80% of Covid-19-positive patients are asymptomatic or have mild cases of the illness that take days or weeks for symptoms to emerge—and many have no symptoms after two weeks, Parshley reports. A smaller percentage of patients have severe cases of Covid-19, which the World Health Organization estimates can take three to six weeks to fully recover from.

But Joseph Brennan, a cardiologist at the Yale School of Medicine, and other experts now worry there may be a subset of patients who suffer long-term damage. For instance, Parshley reports, preliminary research on other coronaviruses, such as severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS), suggest some people can take years to recover.

Parshley rounds up the most notable potential long-term health effects that doctors are observing in Covid-19 patients.


Quote:
Physicians report that patients hospitalized for Covid-19 are experiencing high rates of blood clots that can cause strokes, heart attacks, lung blockages, and other complications, Parshley reports.

For instance, physicians are seeing an uptick in strokes among young patients with Covid-19.

The blood clots also can travel to other organs, leading to ongoing health problems. For instance, pulmonary embolisms, which occur when the clots block circulation to the lungs, can cause ongoing "functional limitations," like fatigue, shortness of breath, heart palpitations, and discomfort when performing physical activity, Parshley reports. Similarly, blood clots in the kidneys can cause renal failure, which can cause life-long complications.


Quote:
Physicians have also reported an increase in inflammation of and damage to the heart muscle in Covid-19 patients. One study published in March found that out of 416 hospitalized Covid-19 patients, 19% showed signs of heart damage.

Another study from Wuhan published in January found 12% of Covid-19 patients showed signs of cardiovascular damage. Other studies have since found evidence of myocarditis, inflammation of the heart muscle that can cause scarring, and heart failure in Covid-19 patients.

Now, physicians warn that Covid-19 survivors may experience long-lasting cardiac damage and cardiovascular problems, which could increase their risk for heart attack and stroke.


Quote:
Physicians have also found evidence of scarring in Covid-19 patients' lungs. According to Parshley, some CT scans show Covid-19 patients have light gray patches on their lungs called "ground-glass opacities," which don't always heal. One Chinese study found the patches in 77% of patients, Parshley reports.


Quote:
Research shows Covid-19 can also affect the central nervous system after patients showed neurological symptoms like headaches, dizziness, loss of taste and smell, and impaired consciousness........As a result, Mitchell Elkind, president-elect of the American Heart Association and professor of neurology and epidemiology at Columbia University, said doctors should be "on the lookout for long-term neurocognitive problems," including decreased concentration and memory as well as dysfunction of the peripheral nerves that lead to the "arms, legs, fingers, and toes."



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monidaw1
Tuesday, August 04, 2020 1:01:29 PM
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I thought this was cute, if a little cruder than I prefer for a happy news thread when I found it.


Quote:
Yes, these are very nice coulds and shoulds, but I'm not entirely convinced that these would actually be enacted on a large scale, leaving many at substantial risk.

It's not for you or me to be convinced, the people who can actually produce them already were convinced and at least they've finally gotten an ear with a couple Congress people.

Quote:
So if somebody becomes infected, it's just because they're stupid. Got it!


So you're suggesting that teachers aren't smart enough to follow basic precautions and sanitary practices that have left as much as 98% of some counties populations uninfected? Day care workers have managed to pull this off. Essential workers from sea to shining sea are doing this every day.

Quote:
By late June, we were seeing deaths nationally average about 500 per day. Yesterday, there was 1,449! As hospitals become more and more crowded and are unable to handle all of the patients, this number will once again begin to explode.

To start with, I have no faith in the numbers being reported are accurate and actually Covid deaths as much as dying from others causes and also having had Covid. What they don't tell you openly is hospitals don't sit around with empty ER beds. There's no money in that. I watched a news broadcast screaming the sky was falling because the ICU bed count was at 100% capacity!!! A minute or so later they say the same hospital a year earlier was only at 95% capacity but we should panic because now 27% of those people are now Covid patients!!. What that tells me is the increase was at the time no more than 5%!!! It also tells me that a substantial number of the people would have been there anyway but are now also Covid patients. That's the only negative I've seen on the "cure" going forward is they're pushing it into the most sick ICU cases 1st and these are the people who will most likely still die even if the Covid is cured since it wasn't the Covid that got them there and curing it will not save them. This appears to be yet another attempt to slow down the product from solving the problem for large numbers of people by testing it where it will do the least good publically, slowing the calls for it. Even with that other companies without direct Chinese ownership and Asian investors in the majority are beginning their trials with nursing home patients now.

In as little as 6 days the Russians may have the 2nd vaccine finalized and beginning distribution. They beat us into space because we sent up monkeys and now they're beating us to a vaccine while we're watching monkeys recover in 100% of the tests. Wall

Either way, hopefully we have something approved in the next month for emergency use here. I'm not going to address long term affects right now because as just reported yesterday in Italy, as many as 98% of the people never got Covid, of the ones that did, over 27% never had symptoms, and 99% of any that died had 1 or more underlying conditions to begin with. It's way too early to believe anything coming out, especially when it appears your actual chances of getting it are amazingly small and remote. Whatever they may be and no matter how bad you think they are, they're just a drop in the bucket compared to the over 500,000 people who will die every single year from smoking and smoking related illnesses including second hand smoke while we continue to do nothing to fight this. THAT"S EVERY SINGLE YEAR!!!!! If anything they're now trying to push smoking weed as a potential Covid CURE???? Lung cancer to go anyone?
Quote:
According to the U.S. Surgeon General, about 480,000 Americans die of smoking-related causes each year, but that figure may be closer to 540,000, researchers from the American Cancer Society report.





4saken1
Wednesday, August 05, 2020 1:15:49 PM
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monidaw1 wrote:
I thought this was cute, if a little cruder than I prefer for a happy news thread when I found it.


monidaw1 wrote:
So you're suggesting that teachers aren't smart enough to follow basic precautions and sanitary practices that have left as much as 98% of some counties populations uninfected? Day care workers have managed to pull this off. Essential workers from sea to shining sea are doing this every day.


It's not just about if individuals take precautions themselves, but what precautions others take as well, or if they are even required to. From what I understand, North Carolina schools won't even require faculty to wear masks! Kaiser Foundation published a study which showed that 1 in 4 U.S. Teachers at Risk of Severe Illness from Coronavirus. I'm sure that you and the genius who wrote that meme above probably are more knowledgeable, though! Grocery store clerks in all of the stores that I've visited have a plastic barrier between the customer and them. Are we planning on sending teachers back in hazmat suits? Rolling on the Floor

monidaw1 wrote:
To start with, I have no faith in the numbers being reported are accurate and actually Covid deaths as much as dying from others causes and also having had Covid.


Are you suggesting that EVERY government in the world and EVERY hospital, and ALL of their employees are lying about the infection rate? That's quite a tin-foil hat theory, there! One could note the change in total mortality rates in 2020 as opposed to previous years, leaving a minor margin for population increase, and assume that much of the difference is likely attributed to COVID-19, being sure to account for any other significant factors at work. Of course, if you think that everybody is just lying about those numbers, too, then that might not be a viable option for you.

monidaw1 wrote:
I'm not going to address long term affects right now because as just reported yesterday in Italy, as many as 98% of the people never got Covid


Yet. Also, source please.

monidaw1 wrote:
and 99% of any that died had 1 or more underlying conditions to begin with.


43% of U.S. Households Report Preexisting Conditions

monidaw1 wrote:
It's way too early to believe anything coming out, especially when it appears your actual chances of getting it are amazingly small and remote.


As more and more people get infected, your chances will increase exponentially. The numbers are pretty dated, but early models predicted that up to 70% of Americans will eventually contract COVID-19. With recent spikes in nearly every state, they might not be very far from the mark.

monidaw1 wrote:
Whatever they may be and no matter how bad you think they are, they're just a drop in the bucket compared to the over 500,000 people who will die every single year from smoking and smoking related illnesses including second hand smoke while we continue to do nothing to fight this. THAT"S EVERY SINGLE YEAR!!!!! If anything they're now trying to push smoking weed as a potential Covid CURE???? Lung cancer to go anyone?
[quote]According to the U.S. Surgeon General, about 480,000 Americans die of smoking-related causes each year, but that figure may be closer to 540,000, researchers from the American Cancer Society report.


......aaaaannnnd this is what they call a red herring and is riddled with numerous other fallacies as well, so I won't even address it.
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MoonKnight1
Wednesday, August 05, 2020 1:53:16 PM
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Smoking cigarettes can cause cancer and you can die from it. It takes years and years (decades?) to die from cancer caused by smoking tobacco. You probably will not die from cigarette caused cancer if you only ever smoke one cigarette in your life.

If you were to catch the Covid once, you could be dead in a week.

People die in car crashes all the time. Happens every day in every place. People who wear seat belts are less likely to die in a car crash than those who are not using one. Masks = Seat Belts.

Off topic slightly - I doubt that it cures Covid, but I have yet to see a consensus that smoking weed causes cancer.

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4saken1
Tuesday, August 11, 2020 11:11:31 AM
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Well here we go! Now we wait and see.....

Russia registers virus vaccine, Putin’s daughter given it
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lcfrick
Tuesday, August 11, 2020 12:40:44 PM
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4saken1 wrote:
Well here we go! Now we wait and see.....

Russia registers virus vaccine, Putin’s daughter given it


Riiiiight, I believe that Putin's daughter received the vaccine just as much I believe that Trump went through a hydroxochloroquine regiment last month.

Hopefully it works, but given that this is likely the product of Russia stealing all of the research from other countries and how many different testing phases they're skipping, I'm not optimistic.

I'd really love to be proven wrong, though.
4saken1
Wednesday, August 12, 2020 10:42:12 AM
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lcfrick wrote:
4saken1 wrote:
Well here we go! Now we wait and see.....

Russia registers virus vaccine, Putin’s daughter given it


Riiiiight, I believe that Putin's daughter received the vaccine just as much I believe that Trump went through a hydroxochloroquine regiment last month.

Hopefully it works, but given that this is likely the product of Russia stealing all of the research from other countries and how many different testing phases they're skipping, I'm not optimistic.

I'd really love to be proven wrong, though.


I'm kinda in the same boat and am highly skeptical of anything that comes out of Russia.
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