Research couple Alec and Linda Holland are working on a top secret formula for bio-restoration...regrowth of human tissue. The government has moved them to a secret lab in the swamps, thinking it will keep them safe. Lt. Matt Cable has been assigned security duty, but fails it miserably when underworld elements find the lab location and try to force the Hollands to hand over the formula. Under the direction of the sinister Mister "E", the Conclave henchmen try to extort the formula from Alec. When he refuses, his lab is bombed, the resulting explosion showering him with both the experimental formula and flames. In agony, Alec plunges his flaming body into the waters, only to undergo a dark genesis into...the Swamp Thing! All of this is watched with great interest by a figure in a nearby castle on a hill.
First appearances of Alec Holland, Linda Holland, Matthew Cable, and Anton Arcane (cameo).