"Death Without Warning!"
The Maggia are holding Doctor Curt Connors' family at Silvermane's behest. The wizened crimelord forces Connors to make a potion from the formula inscribed on a stolen tablet of hieroglyphics.
By the time Spidey arrives, Silvermane has drunk the potion and regained his long-lost youth. This makes him stronger, faster and more dangerous to deal with.
In the chaos that abounds, Curt Connors makes an attempt at finding his family and escaping, but with his adrenaline pumping, the transformation into the Lizard is imminent.
During the battle, Silvermane continues to regress in age, with startling consequences.
Collected in Amazing Spider-Man: The Movie TPB.