House of M: Avengers 1-A

In a world ruled by mutants, Luke Cage's "House of M" origin is revealed. He is set-up for the death of his own girlfriend, by childhood friend Willis Stryker, convicted, and sent to Seagate Prison. In prison, Luke participates in a government 'super-soldier' project and eventually escapes and confronts his 'old friend' Willis.
Then he sets up his own operation in "Sapien Town" and recruits a new group of Sapien Avengers...