Alright, either because you responded to this post or because I executed perhaps more thorough testing that this is working now. LOL. Here were my steps.
CCL Wishlist Testing
-Desktop Software , add Avengers #1 - A (1963) to wish list
-Check website wish list, confirmed online list is updated
-Remove Avengers #1-A (1963) from online wish list
-Find that Avengers #1-A (1963) is NOT removed from desktop software wish list
-Click "Update" in desktop software
-Confirm that desktop software wish list has been updated
-From WEBSITE, add Amazing Spider-Man #1-A (1963) to online wish list
-Check desktop software wishlinst, Amazing Spider-Man #1-A (1963) has NOT been added
-Click "Update"
-Confirm that desktop software wish list has been updated
That being said, I've noticed that the desktop software has not been updated since I believe sometime this past spring 2012? Maybe further back... I saw a "2012 wishlist" thread which has a lot of good suggestions but I didn't see any notification of updates....
I'm as curious as anyone else here

I chose this software because I believe its the best feature set / price point available on the market at this time... There are plenty others more expensive but I think this software and site has the best cost/feature balance for most of us... so I'd definitely like to keep seeing growth!