H. P. Lovecraft's Cthulhu creature comes to life in Batman: The Return of Bruce Wayne #2. Bruce is in 1600s Gotham witnessing the Puritan cleansing of witches while Superman is trying desperately to locate Bruce in the time-stream before the destruction of the time-station. We learn that an ancestor of Bruce plays a key role in witch hunt and that Darkseid is responsible for Bruce's time travel and final destination the 21st Century when/where humanity will perish due to a weapon Bruce carries in his person.
This series is making significant strides in capturing the imagination of the reader and engaging them in serious adventure with intellectual appeal.