"The Desolate Shore"
*The future of mankind hangs in the balance as Abe Sapien finally comes ashore to face the necromancer who’s figured out how to use Abe’s role in the apocalypse to his advantage. *Source: darkhorse.com.
Gustav Strobl finally reveals his plan. Having somehow evolved himself in Abe's path, becoming Icthyo Sapien, he plans to fulfill the destiny that Abe is unwilling to do himself. The only thing in his path is our hero. And during the high-stakes battle, the BPRD, intent on bringing their rogue agent back into the fold, close in.
Issue number 46 in the comprehensive numbering for the series.