"Murder By Spider"
On the same night that Peter Parker is driven, momentarily, into an enraged state while confronting a group of muggers an antiques collector is murdered by an angry clutter of spiders for which of course Spider-Man receives the blame. Believing the two events to be related Peter investigates and is eventually brought face to face with an ingenious nameless foe.
Collected in Spider-Man by Roger Stern Omnibus HC Vol 1.