This is an introductory issue so not much happens apart from establishing the initial group dynamics and introduction of characters.
So the Fantastic Four are no longer and the First Family and Future Foundation have taken their place.
Richard's father has returned from the future, A.I.M. has freed the Wizard, Spider-Man had a new costume and is the replacing member in the FF and Dr. Doom is now part of the family.
Hickman has certainly modernized the franchise and given it a similar feel to the FF as he did to S.H.I.E.L.D. I'm game, we shall see what this reboot will do to the legendary FF.