In my not so humble opinion, in order for Deadpool to work as a solo series it has to be an equal blend of action, humour and dark/gritty reality. The problem with his past series has been that the comedy starts to take centre stage over the action and dark storytelling. This issue is a perfect example of this flaw.
While still an okay read, issue six spends too much time showing Deadpool cracking wise and fails to progress as a story. It is not wise to use Deadpool in "two issues and out" storylines. If you think back to his recent climb back to fame, it all revolved around Wade having a genuine purpose in the Marvel Universe (to help Nick Fury take down the Skrulls.) The readers ate that up, and it catapulted sales of the comic to the top.
This story though seems to be falling back into the old pattern:
1.Deadpool walks into a bar only to find Rhino. They fight, Deadpool wins treating us to a series of jokes.
2.Deadpool falls into the water to find Tigershark. They fight, Deadpool wins treating us to a series of jokes.
3. Deadpool books a flight only to find Vulture on the plane. They fight, Deadpool wins treating us ....
You get the idea!
Why not involve Deadpool with the Thunderbolts? Or retain his services to track down Hardball from the Initiative? If you provide him with B-List storylines, he becomes a B-list character.
Paco Medina's art was its usual stellar self. Daniel Way though seems to be growing bored with this book. There are a few good moments (like when Deadpool's body washes up on the beach), but all in all I thought the book was a bit of a let down.